OPTIMIZE definition: to make as effective, perfect, or useful as possible. See examples of optimize used in a sentence. We need to optimize our use of the existing technology. If you optimize the production process you could speed up the assembly line dramatically. Trailers have also long been optimized to reach their target … Find 53 different ways to say OPTIMIZE, along with antonyms, related words, and example sentences at Thesaurus.com. To optimize a plan, system, or machine means to arrange or design it so that it operates as smoothly and efficiently as possible. Definition of Optimize in the Definitions.net dictionary. What does Optimize mean? Information and translations of Optimize in the most comprehensive dictionary definitions resource … op•ti•mize (op′ tə mīz′), v., -mized, -miz•ing. to make as effective, perfect, or useful as possible. to make the best of. Computing to write or rewrite (the instructions in a program) so as to maximize efficiency … The meaning of OPTIMIZE is to make as perfect, effective, or functional as possible. How to use optimize in a sentence. Optimize definition: To make as perfect or effective as possible.